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Application Area
Bioconjugates manufacturing & the advances with single-use technology
The manufacturing of bioconjugates is a complex process that involves linking a drug payload with a targeting moiety using a linker. The process is highly specific and requires careful optimization to ensure that the bioconjugate is effective and safe for use in patients. Single-use technology has revolutionized the manufacturing of bioconjugates by offering a range of benefits over traditional stainless-steel manufacturing. Therefore, this article will pay special attention to this subject.
Brian Moloney
April 24, 2023
Application Area
Bioconjugation simply explained
Bioconjugation is a pharmaceutical technique that is gaining more and more importance, most of all in cancer therapy. In this article, we will provide some basic information on bioconjugation, but also discuss major challenges related to this field.
Michael Mühlegger
April 20, 2023
Application Area
What is autologous?
The term "autologous" is most frequently found in the context of cell therapy. In this article, we will therefore take a closer look at this revolutionary therapeutic approach.
Michael Eder
April 20, 2023
Application Area
What is allogeneic?
What does "allogeneic" mean, precisely? How do allogeneic cell therapies work, and what is the difference to autologous approaches? Questions like these will be answered in this article.
Michael Eder
April 19, 2023
Application Area
History & Development of ADCs
Since the first ADCs entered clinical trials in the 1990s, they have shown great promise in treating a variety of cancers and other diseases. However, the development of ADCs has also been marked by challenges and setbacks, including issues with efficacy, safety, and manufacturing. In this article, we will explore the history of ADCs, from their early development to the latest advances in technology and applications.
Michael Eder
April 14, 2023
Application Area
Dry to Die: How Spray Drying can be Replaced by Freezing in the Production of Bulk Intermediates
Spray drying often leads to product losses of mAbs or vaccines of more than 30%. Plate-based freezing and thawing solutions enable controlled handling of bulk intermediates safely in a vendor-independent, modular and scalable fluid and cold chain management process.
Daniel Tischler
April 12, 2023
Application Area
Microbial Fermentation Manufacturing: Advances through single-use technologies
Microbial fermentation is a powerful, flexible microbiology process used to generate microbial cells or biomass such as proteins and enzymes for the production of vaccines and therapeutics. There are still some challenges to overcome. Many of these challenges in fermentation manufacturing can be solved by replacing traditional systems with single-use technologies.
Daniel Tischler
March 17, 2023
Application Area
Challenges in microbial fermentation manufacturing
Microbial fermentation manufacturing is an effective method for the production of APIs, bioconjugates and smaller biologicals that play an important role in biotechnology and the production of biopharmaceuticals. Manufacturers face different challenges during microbial fermentation. Explore the 7 biggest challenges, followed by the introduction of new solutions.
Daniel Tischler
March 16, 2023
Application Area
Filling & Freezing large volumes for fermentation in less than 8 hours
The filling and freezing of large volumes for fermentation is an essential part during different production steps in upstream and downstream processing. In the following, we will explain why it is important to act fast and how an optimization of the process can be achieved.
Daniel Tischler
March 16, 2023
Application Area
Cold chain handling for fermentation: Single-use solutions to lower costs
As expert for cold chain handling in bioprocessing, Single Use Support is providing solutions to meet challenges for safe storing and shipping associated with right freezing and thawing methods and temperature control for long-term storage. Their development approach leads to innovative systems that enable manufacturers to replace manual processes with fully automated end-to-end processes that not only push efficiency but also increase output.
Alexander Fuchs
March 14, 2023
Application Area
Microbial cGMP production: complete guide & manufacturer's overview
Microbial fermentation is a hot topic not only in the biopharma industry. In this article, you will find a brief overview of microbial fermentation manufacturing before we discover different CDMOs offering microbial cGMP production.
Michael Mühlegger
March 9, 2023
Application Area
Reducing product loss & human error in pharmaceutical fermentation
Pharmaceutical manufacturing processes, including pharmaceutical fermentation, are still prone to human error and product loss. The challenges can be overcome by moving to automated processes that eliminate the need for slow and error-prone manual handling. Adopting automated end-to-end solutions based on single-use technologies minimizes, if not eliminates, human error and product loss.
Daniel Tischler
February 28, 2023
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