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History of Fermentation: The journey from brewing to advanced therapies

Fermentation has been with mankind at least since the first settlements in the Middle East about 12,000 years ago. Today, scientists have gained so much knowledge about microorganisms and the fermentation process that pharmaceutical manufacturers are using it for the production of vaccines or bioconjugates like ADCs (antibody-drug conjugates) and the development of advanced therapies.

Michael Eder

February 17, 2023

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Fermentation in the pharmaceutical industry: A complete guide

Fermentation in the pharmaceutical industry is used to cultivate microorganisms for antibiotics, therapeutic proteins, enzymes and insulin. It typically involves temperature-controlled tanks, also known as fermenters and the correct concentration of nutrients to cultivate the desired organism. Microbial and bacterial fermentation technology and the associated processes open new possibilities and are important building blocks for gene-editing, conjugates and DNA plasmids used in modern vaccine production.

Daniel Tischler

February 17, 2023

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Precision Fermentation simply explained

Precision fermentation uses microbial hosts to produce a particular end product. Other terms used for precision fermentation are bacterial and microbial fermentation. 

Precision fermentation is used in a variety of ways in both the food industry and pharmaceutical industry to produce biopharmaceuticals. Read more!

Michael Eder

February 14, 2023

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Microbial Fermentation simply explained

Microbial fermentation is a biochemical process that manages to extract chemical energy from carbohydrates without the oxygen. 

This chemical reaction occurs in bacteria, yeasts or even in muscles of humans. Read more details!

Michael Eder

February 14, 2023

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Differences between microbial fermentation & mammalian cell culture

Microbial fermentation in bacteria, yeast or fungi is, due to its benefits, preferred in the production of smaller biologics. These include peptides, proteins, cytokines, growth factors, plasmid DNA, single-domain antibodies, peptibodies and more. Continue reading...!

Daniel Tischler

February 14, 2023

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ADC companies: Big players working with antibody drug conjugates

The antibody-drug conjugates (ADCs) market is expected to grow significantly in the next few years. But what are the key players in this competitive landscape? Find out more in this article!

Michael Eder

November 7, 2022

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Controlled freezing of ADCs

Antibody-drug conjugates might revolutionize the treatment of cancer and various other diseases. However, there are some challenges to overcome in their handling, including controlled freezing – find out more in this article!

Johannes Kirchmair

October 13, 2022

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Viral vectors for gene therapy: What to expect in 2023

Viral vectors are looking ahead a bright future in gene therapies. In this article, we give you an overview of the most frequently used viral vectors and have a glimpse at their possible future applications.

Daniel Tischler

October 11, 2022

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Small batch manufacturing & fill-finish in cell and gene therapy

A great example is the treatment of insidious cancers with CAR T-cells, that relies on modifying the patient’s own T-cells to instill them with a targeted way to fight cancer cells. Learn more why forming strong collaborations will solve many issues!

Michael Mühlegger

October 10, 2022

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Simplifying Cryopreservation of Cell Monolayers

Advanced cell-based assay workflow with CryoLogyx Thaw and Test pre-plated cell and controlled, scalable freezing process solution RoSS.pFTU to achieve effective cryopreservation of cells.

Brian Moloney

August 9, 2022

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CAR-T manufacturing process and the supply chain behind it

Mastering the complex CAR T manufacturing process and the associated supply chain challenges in the cell and gene area are the major bottlenecks during the large-scale commercialization of highly promising CAR T cell products. 

Michael Eder

June 23, 2022

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Gene therapy manufacturing - 5 requirements to scale up

Gene therapies have become a highly promising field of groundbreaking next generation treatment, but there are some challenges to face within the manufacturing process. Here are 5 factors that will be crucial for upscaling gene therapy manufacturing with single-use technology.

Michael Mühlegger

June 9, 2022