All articles about Application Area
Application Area
Biologics vs. Biosimilars: What is the difference?
Biologics and biosimilars are both innovative and frequently used therapeutics, but where do they differ? They will be uncovered in this article.
Michael Eder
May 6, 2024
Application Area
Freezing biologics – best practices
There is more than one way to prepare biologics for long-term storage under temperature-controlled conditions – in this article, we will explore some of the main freezing methods.
Alexander Fuchs
May 6, 2024
Application Area
ADC manufacturing: Process, Challenges & Solutions
Scale-up and industrial production of ADCs face complications due to the high safety measures which need to be taken to guarantee product efficacy and a protected working environment for staff and manufacturers. In this article we seek out to give you an overview of the different challenges during ADC manufacturing while also introducing solutions which help to ensure aseptic production methods through single-use-technologies and end-to-end systems.
Brian Moloney
May 5, 2024
Application Area
Study: Optimizing Cell Viability During CHO Cell Freezing
In a recent study, freezing protocols were tested with the RoSS.LN2F controlled liquid nitrogen freezer to find the optimal freezing rate for CHO-K1 cells in order to achieve maximum cell viability.
Alexander Fuchs
February 16, 2024
Application Area
Who manufactures monoclonal antibodies? Overview of mAb companies
In this article we take a closer look at the top five companies in terms of annual revenue in the U.S., that dominate the field of antibody research, development and production. Further, we dive in the field of promising pioneers with a focus on mAb production for the use of cancer treatments.
Michael Eder
February 12, 2024
Application Area
Stressing Cells: The Role of Cryoprotectants in ATMP Cryopreservation
The objective of an optimal cryopreservation strategy is to deactivate (put on hold) degenerative cellular pathways and preserve proliferative potential by reducing the temperature below –130°C. To reduce the effects of ice crystal and osmotic injuries, cryopreservation protocols usually incorporate cryoprotective agents (CPAs).
Khalil Essani
February 8, 2024
Application Area
Regulations for Cryoprotectants in ATMP Cryopreservation
Adequate quality control samples retained before cell therapy treatment are a crucial component of effective regulation and need to represent the conditions and history in the cryobag. A deep dive into GMP Annex 1 on ATMP Cryopreservation.
Khalil Essani
February 7, 2024
Application Area
Solutions for mAb development and manufacturing
Monoclonal antibody development and manufacturing are highly specialized processes, demanding equally specialized equipment. We will discuss some essential tools and systems in this article.
Brian Moloney
February 7, 2024
Application Area
Safe handling of monoclonal antibodies: Best practices
Monoclonal antibodies bring along some special requirements in terms of safe handling. In this article, we will discover what these requirements are, and how they can be met.
Claus Exenberger
February 7, 2024
Application Area
Steps in Monoclonal Antibody Production
From the selection of antigens to the utilization of bioreactors, each stage in the production journey significantly contributes to the quality, specificity, and scalability of monoclonal antibodies. With a focus on single-use technologies, we explore how innovations are shaping the future landscape of mAb production.
Khalil Essani
February 6, 2024
Application Area
The 3 Most Overlooked Costs in Monoclonal Antibody Production
In the quest for efficient monoclonal antibody manufacturing, it's imperative to shed light on costs that are frequently underestimated. These costs can stem from various sources, including process development, high prices associated with biotherapeutics, and the evolving landscape of production technologies.
Daniel Tischler
February 6, 2024
Application Area
Challenges in monoclonal antibody production
mAb production requires high levels of expertise and precision, as well as specialized equipment. Nonetheless, there are several challenges that manufacturers have to deal with.
Alexander Fuchs
February 6, 2024
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