Freeze & Thaw
To control cryogenic freezing is not an easy task, especially when liquid nitrogen is involved. To keep small molecules chemically stable and prevent chemical degradation, the right practices have to be in place. Find out everything about controlled cryogenic freezing with LN2 in this article!
Daniel Tischler
November 8, 2022
Freeze & Thaw
Antibody-drug conjugates might revolutionize the treatment of cancer and various other diseases. However, there are some challenges to overcome in their handling, including controlled freezing – find out more in this article!
Johannes Kirchmair
October 13, 2022
Freeze & Thaw
Cryopreservation is an effective procedure for the quality-preserving storage of many biomaterials. Find out what cryopreservation actually is, what has to be considered along the process and where it is applied – all summed up in this article.
Daniel Tischler
August 1, 2022
Freeze & Thaw
Temperature plays a significant role in the production and distribution of several revolutionary biologics. But how does the pharmaceutical cold chain work, and what temperature ranges are most frequently chosen? You will find out in this article!
Alexander Fuchs
July 25, 2022
Freeze & Thaw
Implementing cold freezing and storing in supply chains is oftentimes inevitable when dealing with certain biopharmaceuticals. Learn what the main considerations are and find out how to face related challenges.
Daniel Tischler
July 19, 2022
Freeze & Thaw
Plate freezing is a process where a product’s temperature is reduced by the means of contact with cold surfaces. Thus, a defining step in the freeze-thaw process for conservation, with several advantages for biopharma.
Alexander Fuchs
May 18, 2022
Freeze & Thaw
In a comprehensive study the impact of ice front growth speed on scalability of freezing protein solutions has been evaluated.
Michael Eder
February 15, 2022
Freeze & Thaw
What do you need for scalable freezing of biopharmaceuticals in single-use bags?
Check out our Scalability Guide.
Michael Eder
August 9, 2021
Freeze & Thaw
A fast and accessible after-sales service bring along numerous advantages for any manufacturer of biopharmaceuticals, be it CMOs, CDMOs or developing biotech companies. Here’s an overview of the most important aspects that cover a good after-sales support.
Roland Jenewein
August 3, 2021
Freeze & Thaw
In order to preserve biopharmaceutical properties, bulk drug substances are commonly frozen before they are being stored or sent on their way around the globe. Read more about the players and their innovations!
Michael Eder
June 29, 2021
Freeze & Thaw
Single Use Suppport’s RoSS (robust storage and shipping) shell, composed of an outer sleeve of robust stainless-steel and an adaptive inner layer of 3D foam, contributes to a safe journey. It warrants the single-use bag’s intact arrival at its final destination, keeping its precious contents protected from biocontamination and other damages.
Claus Exenberger
May 20, 2021
Freeze & Thaw
How x-ray views from frozen single use bags affirm plate-based freezers as spearheaded freezing technology in Biopharma
Johannes Kirchmair
May 12, 2021
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E-Book
The process of freezing can lead to a denaturation of the protein. In fact, parts of the protein solution will always show less activity based on the stress the protein is exposed to during freezing and thawing. It is therefore important to optimize the freezing and thawing process in order to minimize activity loss. A key parameter for this process is the freezing or thawing rate.
E-Book
Scalability around freezing means the ability to guarantee constant freezing kinetics on proteins (biopharmaceutical molecules) in all scales, filling volumes and loading scenarios. This guide covers how to achieve scalable freezing & thawing of biopharmaceuticals by showing What is scalability? Setup for controlled icefront growth speed Scalability results Outcomes
E-Book
The study was conducted aiming to optimize the cryogenic freezing process of the mammalian CHO-K1 cell line with an innovative controlled rate liquid nitrogen freezer (RoSS.LN2F). The study incorporated three viability assays to comprehensively assess the impact of varying freezing rates on post-thaw cell recovery | Trypan blue | LIVE/DEAD | Fluorescence.