Knowledge
March 13, 2024
Overview of filter integrity testing methods
There are various approaches to validate the integrity of sterile filters, as is required by several regulatory frameworks. We will cover some of the most common methods in this article.
March 12, 2024
Top 7 pharmaceutical CDMOs in 2024
Progress in the pharmaceutical industry is significantly driven by CDMOs, collaborating with pharma companies. In this article, we will put 7 outstanding CDMOs in the spotlight.
March 12, 2024
CMO vs. CDMO: What are the differences?
Both CMOs and CDMOs are frequently relied on partners in the pharmaceutical industry. But what sets them apart, where are their strengths, and what do they offer?
March 5, 2024
Single-use bag manufacturers: the major players
The advanced platforms of the newest generation of single use bags are generally compatible with a variety of bag brands and volumes. One of these platforms is Single Use Support’s RoSS®, which offers the benefit of not only being bag agnostic but also highly flexible thanks to its modular design. Learn more about the biggest player in the industry!
February 16, 2024
Study: Optimizing Cell Viability During CHO Cell Freezing
In a recent study, freezing protocols were tested with the RoSS.LN2F controlled liquid nitrogen freezer to find the optimal freezing rate for CHO-K1 cells in order to achieve maximum cell viability.
February 12, 2024
Who manufactures monoclonal antibodies? Overview of mAb companies
In this article we take a closer look at the top five companies in terms of annual revenue in the U.S., that dominate the field of antibody research, development and production. Further, we dive in the field of promising pioneers with a focus on mAb production for the use of cancer treatments.
February 8, 2024
Stressing Cells: The Role of Cryoprotectants in ATMP Cryopreservation
The objective of an optimal cryopreservation strategy is to deactivate (put on hold) degenerative cellular pathways and preserve proliferative potential by reducing the temperature below –130°C. To reduce the effects of ice crystal and osmotic injuries, cryopreservation protocols usually incorporate cryoprotective agents (CPAs).
February 7, 2024
Regulations for Cryoprotectants in ATMP Cryopreservation
Adequate quality control samples retained before cell therapy treatment are a crucial component of effective regulation and need to represent the conditions and history in the cryobag. A deep dive into GMP Annex 1 on ATMP Cryopreservation.
February 7, 2024
Solutions for mAb development and manufacturing
Monoclonal antibody development and manufacturing are highly specialized processes, demanding equally specialized equipment. We will discuss some essential tools and systems in this article.
February 7, 2024
Safe handling of monoclonal antibodies: Best practices
Monoclonal antibodies bring along some special requirements in terms of safe handling. In this article, we will discover what these requirements are, and how they can be met.
February 6, 2024
Steps in Monoclonal Antibody Production
From the selection of antigens to the utilization of bioreactors, each stage in the production journey significantly contributes to the quality, specificity, and scalability of monoclonal antibodies. With a focus on single-use technologies, we explore how innovations are shaping the future landscape of mAb production.
February 6, 2024
The 3 Most Overlooked Costs in Monoclonal Antibody Production
In the quest for efficient monoclonal antibody manufacturing, it's imperative to shed light on costs that are frequently underestimated. These costs can stem from various sources, including process development, high prices associated with biotherapeutics, and the evolving landscape of production technologies.